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Cwele, who is set to start a 20-year prison term, did not speak to waiting journalists. She entered the building smartly dressed in a black dress and a black and white floral coat.
At 9.30am she got into the back of police van that was to take her to Durban's Westville prison. Press photographers waited at the back of the court in a bid to get a last picture of her, while court orderlies did their best to obscure her from their view.
She was expected to arrive at the prison between 10.30am and 11am, where another contingent of photographers was waiting for her at the entrance.
Cwele and her co-accused Frank Nabolisa failed to have their convictions overturned by the Supreme Court of Appeal on Monday. The court also increased their sentences from 12 to 20 years.
Cwele was given three days upon receipt of the judgment to hand herself to authorities.
The two were found guilty of drug dealing by the Pietermaritzburg High Court in May 2011. Both had pleaded not guilty to conspiring to deal in drugs, to procuring a woman, Charmaine Moss, to collect drugs in Turkey, and to procuring another woman, Tessa Beetge, to smuggle cocaine from South America.
Nabolisa had been in custody until now, while Cwele was out on R100,000 bail. She is the former wife of State Security Minister Siyabonga Cwele.
